abstract：PURPOSE:Recent studies suggest new mechanisms of Botulinum toxin (BoNT) other than inhibiting acetylcholine (ACh) release from nerve terminals. The aim of this study was to determine whether other mechanisms for BoNT exist, so that it directly inhibits smooth muscle contraction. MATERIALS AND METHODS:Guinea pig antral...

journal_title：Yonsei medical journal

authors： Park JH,Choi E,Park H,Lee YH

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to identify the adipocyte-specific gene expression patterns in chorion-derived mesenchymal stem cells during adipogenic differentiation. MATERIALS AND METHODS:Chorionic cells were isolated from the third trimester chorions from human placenta at birth and identified morphologically an...

journal_title：Yonsei medical journal

authors： Kim YH,Park TC,Lee G,Shin JC

更新日期：2012-09-01 00:00:00

abstract：:Leptin, a peptide hormone secreted by adipocytes in proportion of the amount of energy stored in fat, plays a central role in regulating human energy homeostasis. In addition, leptin plays a significant permissive role in the physiological regulation of several neuroendocrine axes, including the hypothalamic-pituitary...

journal_title：Yonsei medical journal

authors： Khan SM,Hamnvik OP,Brinkoetter M,Mantzoros CS

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:Neisseria meningitidis is a leading cause of bacterial meningitis in young adults. University students, especially those living in dormitories, have been known to be at increased risk of meningococcal disease. We performed a longitudinal study to determine the carriage rates of N. meningitidis and the changes t...

journal_title：Yonsei medical journal

authors： Durey A,Bae SM,Lee HJ,Nah SY,Kim M,Baek JH,Kang YH,Chung MH,Lee JS

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:To investigate the symptoms of attention deficit hyperactivity disorder (ADHD) as reported by parents in children with intermittent exotropia [X(T)] and to determine whether strabismus surgery for X(T) affects ADHD symptoms. MATERIALS AND METHODS:Fifty-one consecutive children undergoing muscle surgery for X(T...

journal_title：Yonsei medical journal

authors： Chung SA,Chang YH,Rhiu S,Lew H,Lee JB

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:The lateralization of cognitive functions in crossed aphasia in dextrals (CAD) has been explored and compared mainly with cases of aphasia with left hemisphere damage. However, comparing the neuropsychological aspects of CAD and aphasia after right brain damage in left-handers (ARL) could potentially provide mo...

journal_title：Yonsei medical journal

authors： Ha JW,Pyun SB,Hwang YM,Sim H

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:Tumor marker concentrations in a given specimen measured by different analyzers vary according to assay methods, epitopes for antibodies used, and reagent specificities. Although great effort in quality assessment has been instituted, discrepancies among results from different analyzers are still present. We ev...

journal_title：Yonsei medical journal

authors： Park Y,Park Y,Park J,Kim HS

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:To evaluate reliability of Fourier-domain optical coherence tomography (OCT) (RTVue), time-domain OCT (Visante), and slit-lamp adapted ultrasonic pachymetry (SL-US) in the measurement of central corneal thickness (CCT). MATERIALS AND METHODS:Thirty healthy volunteers visited our clinic 3 times and fifty eyes w...

journal_title：Yonsei medical journal

authors： Hong JP,Nam SM,Kim TI,Seo KY,Lee SY,Meduri A,Kim EK

更新日期：2012-05-01 00:00:00

abstract：:The overall prognosis of gastric cancer has gradually improved over the past decades with growing awareness of potential carcinogens, surveillance programs and early diagnosis, as well as advances in surgical techniques and multimodality treatments. Nevertheless, the outcome of advanced stage disease still remains poo...

journal_title：Yonsei medical journal

authors： Lee JH,Kim KM,Cheong JH,Noh SH

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Spontaneous bacterial peritonitis (SBP) frequently develops in patients with liver cirrhosis; however, there is little data to suggest whether the acquisition site of infection influences the prognosis. This study compared the bacteriology, clinical characteristics and treatment outcomes of community-acquired S...

journal_title：Yonsei medical journal

authors： Kim SU,Chon YE,Lee CK,Park JY,Kim DY,Han KH,Chon CY,Kim S,Jung KS,Ahn SH

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:This study determined the seroprevalence of herpes virus 2 in gravidas and the differences between herpes virus 2-infected and healthy gravidas. The need to screen gravidas for herpes virus 2 was also evaluated. MATERIALS AND METHODS:A retrospective analysis involving 500 gravidas who underwent herpes virus 2 ...

journal_title：Yonsei medical journal

authors： Kim ID,Chang HS,Hwang KJ

更新日期：2012-03-01 00:00:00

abstract：:Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterized by periodic episodes of fever and recurrent polyserositis. It is caused by a dysfunction of pyrin (or marenostrin) as a result of a mutation within the MEFV gene. It occurs mostly in individuals of Mediterranean origin; however, it has al...

journal_title：Yonsei medical journal

authors： Koo KY,Park SJ,Wang JY,Shin JI,Jeong HJ,Lim BJ,Lee JS

更新日期：2012-03-01 00:00:00

abstract：:Behçet's disease is a chronic relapsing multisystemic inflammatory disorder characterized by four major symptoms (oral aphthous ulcers, genital ulcers, skin lesions, and ocular lesions) and occasionally by five minor symptoms (arthritis, gastrointestinal ulcers, epididymitis, vascular lesions, and central nervous syst...

journal_title：Yonsei medical journal

authors： Cho SB,Cho S,Bang D

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Elevated C-reactive protein (CRP) is associated with poor prognosis in several tumor types. The purpose of this study was to investigate serum CRP as a prognostic marker in small cell lung cancer (SCLC). MATERIALS AND METHODS:The pretreatment serum CRP level was measured in 157 newly diagnosed SCLC patients, a...

journal_title：Yonsei medical journal

authors： Hong S,Kang YA,Cho BC,Kim DJ

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:During stimulated in vitro fertilization (IVF) cycle, up to 30% of the recovered oocytes are immature ones which have poor fertilization capacity; however, the precise influencing factors are largely unknown. Here, we analyzed the association of oocyte immaturity with woman's age in IVF cycles stimulated by sin...

journal_title：Yonsei medical journal

authors： Lee HJ,Jee BC,Suh CS,Kim SH,Moon SY

更新日期：2012-01-01 00:00:00

abstract：:A 62-year-old male patient with prostate cancer and bilateral renal cell carcinoma underwent a simultaneous robot-assisted bilateral partial nephrectomy and radical prostatectomy. We describe our initial experience of combined operation with a port strategy allowing reuse of ports and surgical considerations because o...

journal_title：Yonsei medical journal

authors： Jung JH,Arkoncel FR,Lee JW,Oh CK,Yusoff NA,Kim KJ,Rha KH

更新日期：2012-01-01 00:00:00

abstract：:Pathogenic bacteria have increasingly been resisting to antimicrobial therapy. Recently, resistance problem has been relatively much worsened in Gram-negative bacilli. Acinetobacter spp. are typical nosocomial pathogens causing infections and high mortality, almost exclusively in compromised hospital patients. Acineto...

journal_title：Yonsei medical journal

authors： Lee K,Yong D,Jeong SH,Chong Y

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Curative surgery for patients with advanced or even early gastric cancer can be defined as resection of the stomach and dissection of the first and second level lymph nodes, including the greater omentum. The aim of this study was to evaluate the short- and long- term outcomes of partial omentectomy (PO) as com...

journal_title：Yonsei medical journal

authors： Kim MC,Kim KH,Jung GJ,Rattner DW

更新日期：2011-11-01 00:00:00

abstract：:Long QT syndrome is associated with lethal tachyarrhythmia that can lead to syncope, seizure, and sudden death. Congenital long QT syndrome is a genetic disorder, characterized by delayed cardiac repolarization and prolongation of the QT interval on the electrocardiogram (ECG). Type 2 congenital long QT is linked to m...

journal_title：Yonsei medical journal

authors： Lim SM,Pak HN,Lee MH,Kim SS,Joung B

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:To evaluate the clinicopathological characteristics and prognosis of localized resectable genitourinary sarcomas in adults. MATERIALS AND METHODS:Between September, 1996 and November, 2008, 18 consecutive cases of adults (12 men and 6 women; median age 48.8 years) who were treated for primary genitourinary sar...

journal_title：Yonsei medical journal

authors： Cho SY,Moon KC,Cheong MS,Kwak C,Kim HH,Ku JH

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To compare the cytological results of ultrasound-guided fine-needle aspiration (US-FNA) cytology of thyroid nodules to sonographic findings and determine whether US findings are helpful in the interpretation of cytological results. MATERIALS AND METHODS:Among the thyroid nodules that underwent US-FNA cytology,...

journal_title：Yonsei medical journal

authors： Lee MJ,Hong SW,Chung WY,Kwak JY,Kim MJ,Kim EK

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:We conducted a multi-center randomized double-blind study to determine the effects of 6-month therapy with sulodexide on urinary protein excretion in patients with idiopathic Immunoglobulin A (IgA) nephropathy. MATERIALS AND METHODS:A total of seventy-seven patients participated in the study. They were randoml...

journal_title：Yonsei medical journal

authors： Bang K,Chin HJ,Chae DW,Joo KW,Kim YS,Kim S,Ju KD,Kim H,Ahn C,Oh KH

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To inform on shoulder pathology and to identify the disabilities and level of quality of life (QOL) associated with shoulder pain in patients with breast cancer- related lymphedema (BCRL). MATERIALS AND METHODS:Using patient history, physical examination, and ultrasound (US), we classified patients with BCRL i...

journal_title：Yonsei medical journal

authors： Jeong HJ,Sim YJ,Hwang KH,Kim GC

更新日期：2011-07-01 00:00:00

abstract：:Pattern recognition receptors (PRRs) in innate immune cells play a pivotal role in the first line of host defense system. PRRs recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) to initiate and regulate innate and adaptive immune responses. PRRs include Toll-like r...

journal_title：Yonsei medical journal

authors： Jeong E,Lee JY

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Massive blood transfusios are uncommon. The goal of this study was to propose an ideal ratio for the blood component of massive hemorrhage treatment after review of five years of massive transfusion practice, in order to have the best possible clinical outcomes. MATERIALS AND METHODS:We defined a 'massive tran...

journal_title：Yonsei medical journal

authors： Yoon S,Park AJ,Kim HO

更新日期：2011-05-01 00:00:00

abstract：:Previously, we reported that epigallocatechin 3-O-gallate (EGCg) has growth-inhibitory effect on clinical isolates of Candida species. In this study, we investigated the antifungal activity of EGCg and antifungal agents against thirty-five of dermatophytes clinically isolated by the international guidelines (M38-A2). ...

journal_title：Yonsei medical journal

authors： Park BJ,Taguchi H,Kamei K,Matsuzawa T,Hyon SH,Park JC

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Growing evidence suggests that hypoadiponectinemia may play a significant role in the development of metabolic syndrome (MetS). Therefore, the relationships between serum adiponectin with MetS and components of MetS were investigated in non-diabetic samples of drawn from the Koreans general population. MATERIA...

journal_title：Yonsei medical journal

authors： Koh SB,Yoon J,Kim JY,Yoo BS,Lee SH,Park JK,Choe KH

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:PCR is widely used for rapidly and accurately detecting Mycobacterium species. The purpose of this study was to assess the diagnostic performance of three real-time PCR kits and evaluate the concordance with two older PCR methods. MATERIALS AND METHODS:Using 128 samples, the five PCR methods were assessed, inc...

journal_title：Yonsei medical journal

authors： Cho SY,Kim MJ,Suh JT,Lee HJ

更新日期：2011-03-01 00:00:00

abstract：:We present the case of an 81-year-old patient with testicular metastasis from prostate carcinoma. After the initial diagnosis of prostate cancer, he had an 8-year course of hormonal therapy and showed no clinical evidence of metastasis to other organs. Asymptomatic metastasis of prostate carcinoma to the testis is a r...

journal_title：Yonsei medical journal

authors： Kim SO,Choi YD,Jung SI,Oh KJ,Im CM,Kang TW,Kwon D,Park K,Ryu SB

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:Stroke is the second leading cause of death and a major cause of morbidity and mortality worldwide. Evidence of variations in adiponectin (AdipoQ) genes that are associated with ischemic stroke has not been consistent, and it is unclear whether the same loci contribute to these associations in the Korean popula...

journal_title：Yonsei medical journal

authors： Cheong MY,Bang OS,Cha MH,Park YK,Kim SH,Kim YJ

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Our study is performed to find out clinicopathlogic and immunohistochemical (IHC) characteristics of triple negative invasive lobular carcinoma (ILC), as has been demonstrated in their invasive ductal counterparts. MATERIALS AND METHODS:Retrospective analysis of variable clinicopathlogic parameters and IHC sta...

journal_title：Yonsei medical journal

authors： Koo JS,Jung W

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during both adipogenesis and osteogenesis of human bone marrow-derived stem cells (BMSCs). ...

journal_title：Yonsei medical journal

authors： Jung HS,Kim YH,Lee JW

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:This research compares the predictive value of the abdominal obesity indicator, waist circumference (WC), and the overall obesity indicator, body mass index (BMI), among men and women with regard to type 2 diabetes. MATERIALS AND METHODS:This study used data collected from 4,400 households selected by a strati...

journal_title：Yonsei medical journal

authors： Paek KW,Chun KH

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:The effects of air cleaners on the removal of airborne indoor allergens, especially house dust mites (HDM), are still controversial. The objective of this study is to evaluate the effect of an air cleaner with an electrostatic filter on the removal of airborne mite allergens. MATERIALS AND METHODS:A dried HDM ...

journal_title：Yonsei medical journal

authors： Agrawal SR,Kim HJ,Lee YW,Sohn JH,Lee JH,Kim YJ,Lee SH,Hong CS,Park JW

更新日期：2010-11-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis, and it can be classified as either a functional or nonfunctional tumor. Affected patients usually present with abdominal pain or with symptoms related to the mass effect or hormonal activity of the tumor. Several cases of spontaneously ruptured n...

journal_title：Yonsei medical journal

authors： Chung JO,Cho DH,Lee JH,Kwon DD,Chung DJ,Chung MY

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Mitochondrial encephalopathy (ME) is a rare disorder of energy metabolism. The disease course can roughly be evaluated by clinical findings. The purpose of this study was to evaluate metabolic spectral changes using proton MR spectroscopy (MRS), and to establish a way to monitor ME by neuroimaging. MATERIALS A...

journal_title：Yonsei medical journal

authors： Lee SK,Kim J,Kim HD,Lee JS,Lee YM

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Several signaling pathways have been shown to regulate the lineage commitment and terminal differentiation of bone marrow stromal cells (BMSCs). Bone morphogenetic protein (BMP) signaling has important effects on the process of skeletogenesis. In the present study, we tested the role of bone morphogenetic prote...

journal_title：Yonsei medical journal

authors： Wang A,Ding X,Sheng S,Yao Z

更新日期：2010-09-01 00:00:00

abstract：:A 71-year-old man was stable on warfarin (2.25 mg daily) therapy with an international normalized ratio (INR) of 1.8-2.2 after a heart valve replacement surgery. Recently, he consumed the liquid-like herbal product called shengmai-yin (10 mL daily) against medical advice. Seven days after the daily consumption of shen...

journal_title：Yonsei medical journal

authors： Su Q,Li Y

更新日期：2010-09-01 00:00:00

abstract：:After glioma pathogenesis-related protein 1 (GLIPR1/Glipr1) was identified, the expression of GLIPR1 was shown to be down-regulated in human prostate cancer, owing in part to methylation in the regulatory region of this gene in prostate cancer cells. Additional studies showed that GLIPR1/Glipr1 expression is induced b...

journal_title：Yonsei medical journal

authors： Thompson TC

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The objective of this study is to define the clinical implications of consolidations in nodular bronchiectatic type Mycobacterium avium complex (NBMAC) infection. MATERIALS AND METHODS:A total of 69 patients (M : F = 17 : 52; mean age, 64 years; age range, 41-85 years) with MAC isolated in the sputum culture a...

journal_title：Yonsei medical journal

authors： Im SA,Park HJ,Park SH,Chun HJ,Jung WS,Kim SH

更新日期：2010-07-01 00:00:00